Familial Paget's disease's with early onset.

now accepted that Paget’s disease may run in families, though uncommonly. The family with Paget’s disease reported here consists of a father and two daughters. The father’s case is of interest because of the rare type of malignant change which led to his death, and the affection in the two daughters is notable for the unusually early onset at eighteen years. There are three other siblings, two brothers and a sister, who are all in the fourth decade of life. None presents any clinical abnormality and radiographic examination of their skulls and pelves showed no skeletal changes.